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The game is a highly strategic and powerfully feline version of Russian Roulette.
Players draw cards until someone draws an Exploding Kitten card, at which point that someone explodes, is out, and is out of the game.
Unless that player has a Defuse card in their hand that can defuse the Exploding Kitten card, just as laser pointers, belly rubs, or catnip sandwiches would.